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If it is a regular tablet, then swallow it whole with a full glass of water But medicines are very important, so one can either learn (or teach children) how to swallow pills, or use creative ways to make it easier to take the medicine by cutting it, crushing it, chewing it, opening a capsule, or mixing it or dissolving it in a pleasant-tasting liquid or soft food The List of Oral Dosage Forms That Should Not Be Crushed, commonly referred to as the "Do Not Crush" list, contains medications that should not be crushed because of their special pharmaceutical formulations or characteristics, such as oral dosage forms that are sustained-release in nature.. Also, what about putting some of the crushed powder on the site of a dental infection similar to the way they older timers bit on an aspirin for pain relief. If you have a cold, you're right, it will do nothing, as a cold is a virus and antibiotics don't kill viruses. It will take 2 - 3 days before you see any change. 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